一、基本情况
张新科，女，博士，正高级职称，博士生导师；
35222葡京集团新药药理研究所,35222葡京集团新药创制筛选平台工作。
Tel：0531-88382490；
E-mail: zhangxinke@sdu.edu.cn
二、学习经历
2009/9-2012/6，3522集团的新网站，35222葡京集团微生物与生化药学研究所，博士；
2006/9-2009/6，3522集团的新网站，35222葡京集团药剂所，硕士；
2002/9-2006/6，3522集团的新网站，35222葡京集团，学士
三、工作经历
正高：2023.09-至今 35222葡京集团生物药物与糖类药物研发团队
副高：2017.09-至今35222葡京集团新药药理研究所新药筛选平台
访问学者：2018.03-2019.09美国加州大学戴维斯分校
中级：2012.07-2017.08，35222葡京集团新药药理研究所新药筛选平台
四、研究方向
1.纳米制剂递送给药
针对血管增生性疾病（肿瘤、糖尿病视网膜病变等），致力于研究高效穿透血脑屏障或眼球屏障的纳米靶向制剂。
2.蛋白多肽类研究
主要致力于融合蛋白的表达、纯化及活性研究；设计筛选多功能靶向穿膜肽使其用于血管增生性疾病的治疗
3.外泌体的研究
对间充质干细胞外泌体的产量、工程化及活性评价研究，致力于外泌体对神经系统疾病及皮肤疾病的治疗。
五、承担的科研项目（纵向）
1.国家自然科学基金面上项目，神经元靶向的载药细胞外囊泡的构建及对脑缺血再灌注神经元损伤的保护作用及机制研究，主持，立项日期，2023.01。
2.山东省自然科学基金面上项目，新型穿膜双靶向肽TAT-AT7对神经胶质瘤的靶向治疗作用及机制研究，立项日期，2021/01
3.山东省重点研发计划，主动靶向肽A7介导的载TatPTD-内皮抑素基因壳聚糖纳米载体治疗眼部血管增生疾病的成药性研究,立项日期，2016/09。
4.国家自然科学基金项目，双修饰壳聚糖载TatPTD-内皮抑素基因纳米粒靶向抑制眼底血管增生的研究，立项日期2014/01
六、承担教学工作
生物技术制药实验、药理学实验、临床药理学实验
七、代表性学术论文
1.Jing Liao, Lin Zhao, Hongyuan Chen, Chunqian Zha, Shang Chen, Xiuli Guo, Fengshan Wang, Xiaoxue Liu,Xinke Zhang(通讯作者).A Bifunctional Peptide with Penetration Ability for Treating Retinal Angiogenesis via Eye Drops. Molecular Pharmaceutics, 2025;22(2):708-720.
2. Weihan Zhang, Shijun Yuan, Zipeng Zhang, Shunli Fu, Shujun Liu, Jinhu Liu, Qingping Ma, Zhenxing Xia, Panpan Gu, Shuying Gao, Zhiyue Zhang,Xinke Zhang（共同通讯）, Yongjun Liu, Na Zhang. Regulating tumor cells to awaken T cell antitumor function and enhance melanoma immunotherapy. Biomaterials,2024. 123034
3. Cui Li, Xiaohan Xu , Xiaoxian Lin, Man Yuan, Dongliang Wang,Xinke Zhang（共同通讯）. Edible bird’s nest plays an immune regulation by influencing intestinal flora changes in mice.Journal of Functional Foods.2024,118,106254.
4.Lu Lu, Longkun Wang, Lin Zhao, Jing liao, Chunqian Zhao, Xiaohan Xu, Fengshan Wang,Xinke Zhang(通讯作者). A Novel Blood–Brain Barrier-Penetrating and Vascular-Targeting Chimeric Peptide Inhibits Glioma Angiogenesis. International Journal of Molecular Sciences. 2023, 24(10), 8753
5.Wei Pan, Hongyuan Chen, Aijun Wang, Fengshan Wang,Xinke Zhang（通讯作者）. Challenges and strategies: Scalable and efficient production of mesenchymal stem cells-derived exosomes for cell-free therapy. Life Sciences. 2023, 319, 121524.
6.Longkun Wang, Chunqian Zhao, Lu Lu, Honglei Jiang, Fengshan Wang,Xinke Zhang（通讯作者）. Transcytosable Peptide-Paclitaxel Prodrug Nanoparticle forTargeted Treatment of Triple-Negative Breast Cancer. International Journal of Molecular Sciences. 2023,24, 4646.
7.Shang Chen,Chenyan Ren,Yuan Ji,Dongke Liu,Xinke Zhang(通讯作者) ,Fengshan Wang.The Pharmacokinetics in Mice and Cell Uptake of Thymus Immunosuppressive Pentapeptide Using LC-MS/MS Analysis.Molecules,2022 ,27(13):4256.
8.Longkun Wang,Hongyuan Chen,Fengshan Wang,Xinke Zhang*(通讯作者). The development of peptide-drug conjugates (PDCs) strategies for paclitaxel. Expert Opin Drug Deliv. 2022,19(2):147-161.
9.Chunqian Zhao,Hongyuan Chen,Fengshan Wang,Xinke Zhang*(通讯作者). Amphiphilic self-assembly peptides: Rational strategies to design and delivery for drugs in biomedical applications. Colloids Surf B Biointerfaces,2021,208:112040.
10.Lin Zhao,Hongyuan Chen,Lu Lu, Chunqian Zhao, Christina V. Malichewe,Lei Wang,Xinke Zhang*(通讯作者),Xiuli Guo.Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma. Life Sciences, 2021,270,119113
11.Lin Zhao,Hongyuan Chen,Lu Lu,Lei Wang,Xinke Zhang*(通讯作者),Xiuli Guo. New insights into the role of co-receptor neuropilins in tumour angiogenesis and lymphangiogenesis and targeted therapy strategies.Journal of Drug Targeting. 2021,29(2):155-167
12.Lu Lu,Hongyuan Chen,Longkun Wang,Lin Zhao,Yanna Cheng,Aijun Wang,Fengshan Wang,Xinke Zhang*(通讯作者).A Dual Receptor Targeting- and BBB PenetratingPeptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma. International Journal of Nanomedicine, 2020, 15: 8875–8892.
13.Lu Lu,Chen Hongyuan,Hao Dake,Zhang Xinke*(通讯作者),Wang Fengshan. The functions and applications of A7R in anti- angiogenic therapy, imaging and drug delivery systems. Asian Journal of Pharmaceutical Sciences.2019,14(6):595-608
14.Xinke Zhang,Peng Li,Shaohua Guo,Shuqi Wang,Dasheng Liu.Quantitation ofβ-carboline and quercetin in alligator weed (Alternanthera philoxeroides (Mart.) Griseb.) by LC-MS/MS and evaluation of cardioprotective effects of the methanol extracts. Drug Discov Ther. 2018;12(6):341-346.
15.Zhang Xinke, Li Yan, Cheng Yanna, Tan Haining，Li Zhiwei, Qu Yi, Mu Guoying, Wang Fengshan.Tat PTD-endostatin: a novel anti-angiogenesis protein with ocular barrier permeability via eye-drops. BBA General Subjects,2015;1850(6):1140-9.
16.Zhang Xinke, Zhang Xue, Wang Fengshan.Intracellular transduction and potential of Tat PTD and its analogs: from basic drug delivery mechanism to application. Expert opinion on drug delivery, 9(4):457-72, 2012.
17.Zhang XinKe, Sun Ping, Bi Ru, Wang Jinping, Zhang Na, Huang GuiHua.Targeted delivery of levofloxacin-liposomes for the treatment of pulmonary inflammation. Journal of Drug Targeting, 17(5):399–407, 2009.
18.Li Pingli,Zhang Xinke, Cheng Yanna , Li Juan , Xiao Yuliang , Zhang Qian, Zong Aizhen, Zhong Chuanqing, Wang fengshan. Preparation and in vitro immunomodulatory effect of curdlan sulfate. Carbohydrate Polymers, 2014, 102: 852– 861
19.Li Juan,Cheng Yanna,Zhang Xinke,Zheng Lei,Han Zhen,Li Pingli,Xi-ao Yuliang,Zhang Qian,Wang Fengshan. The in vivo immunomodulatory and synergistic anti-tumor activity of thymosin α1-thymopentin fusion peptide and its binding to TLR2.Cancer Lett.2013,337(2):237-47
