基本情况：

彭明，博士，35222葡京集团副研究员，硕士研究生导师，天然药物化学专业，3522集团的新网站青年学者未来计划入选者。主要从事微生物活性天然药物生物合成及药物和靶标的结构生物学研究，以生物信息学、结构生物学、分子生物学、生物化学等为主要研究手段，揭示天然药物生物合成关键步骤的分子机制，实现药物合成工具酶理性开发。作为项目负责人主持国家自然科学基金青年基金项目、山东省自然科学基金青年基金项目、中国博士后科学基金面上项目等国家级和省部级课题。以（共同）第一/通讯作者的研究成果相继发表在Nature Microbiology、Nature Communications、JACS、ACS Catalysis等国际主流期刊。

通讯地址：山东省济南市文化西路44号，35222葡京集团

Email:pengm@sdu.edu.cn

研究方向：

1.天然药物合成酶的深度挖掘、三维结构及分子机制解析

2.药物和靶标的结构生物学

3.药物合成工具酶的理性改造及开发

学习及工作经历：

2022.8-至今 35222葡京集团 副研究员

2020.7-2022.73522集团的新网站微生物技术国家重点实验室 博士后

2015.9-2020.63522集团的新网站微生物技术国家重点实验室 博士

主持/参与课题：

1.国家自然科学基金青年基金项目，42106142，2022.1.1-2023.12.31 ,主持

2.山东省自然科学基金青年基金项目，ZR2021QD071，2022.1.1至2024.12.31，主持

3.中国博士后科学基金面上项目，2021M691914，2021.7.1-2023.6.30，主持

4.青岛市博士后研究人员应用项目资助，62450071311033，2021.1.1-2022.12.31，主持

5.微生物技术国家重点实验室开放课题面上项目，M2023-19，2023.7.1-2025.6.30，主持

6.3522集团的新网站青年学者未来计划项目，2023.1.1-2027.12.31，主持

7.35222葡京集团基本科研业务费资助项目，2022.1.1-2024.12.31，主持

8.国家自然科学基金重大研究计划项目，91851205，2019.1.1-2022.12.31，参与

9.国家自然科学基金重大研究计划项目，91751101，2018.1.1-2020.12.31，参与

10.国家自然科学基金面上项目，32070109，2020.1.1-2022.12.31，参与

11.国家自然科学基金面上项目，31670038，2017.1.1-2020.12.31，参与

代表性学术论文：

1.Peng M^#, Li CY^#, Chen XL, Williams BT, Li K, Gao YN, Wang P, Wang N, Gao C, Zhang S,Schoelmerich MC, Banfield JF, Miller JB,Le Brun NE, Todd JD^*, Zhang YZ^*Insights into methionineS-methylation in diverse organisms.Nature Communications.2022, 13:2947. Doi : 10.1038/s41467-022-30491-5.(1区,IF: 16.1)

2.Carrión O^#*, Li CY^#*,Peng M^#(co-first author), Wang J, Pohnert G, Azizah M, Zhu XY, Curson ARJ, Wang Q, Walsham KS, Zhang XH, Monaco S, Harvey JM, Chen XL, Gao C, Wang N, Wang XJ, Wang P, Giovanonni SJ, Lee CP, Suffridge CP, Zhang Y, Luo Z, Wang D, Todd JD^*, Zhang YZ^*. DMSOP cleaving enzymes are diverse and widely distributed in marine microorganisms.Nature Microbiology, 2023, 8(12): 2326-2337. Doi: 10.1038/s41564-023-01526-4. (1区,IF: 21)

3.Peng M^#, Wu QL^#, Ma LL, Teng ZJ, Hou XB, Zhu HJ^*, Ju JH^*. Bacterial Biosynthesis of Nitrile-Containing Natural Products: Basis for Recognition of Diversified Substrates.ACS Catalysis, 2024, 14, 17780−17793. DOI: 10.1021/acscatal.4c06581. (1区,IF: 12.8)

4.Chen J^#, Zhu HJ^#,Peng M^#(co-first author), Zhang SW, Li QL, Gu YC, Ju JH^*. Flavin-Dependent Monooxygenase Kmy13 Mediates Formation of the CarbocyclicansaSystem during Kendomycin B Biosynthesis.J. Am. Chem. Soc.2024, 146, 28242−28249.Doi: 10.1021/jacs.4c08774. (1区, IF: 14.8)

5.Chen YY^#, Jing LQ^#,Peng M^#(co-first author), Cai CL, Shi JJ, Ge W, Liu Y, Shang Z, Ma JY^*, Wu DL^*, Ju JH^*. Enzymatic Insights into the Unusual Formation of Benzolactone and Benzopyran in the Biosynthesis of Spiromarmycin.ACS Catalysis, 2025, 15, 2809−2821.DOI: 10.1021/acscatal.4c07664. (1区,IF: 12.8)

6.Wang Y^#, Wang Z^#, Zhao WX, Yuan XJ, Yu Y, Wang P, Wang M, McMinn A, Zhang YZ,Peng M^*(co-corresponding author), Fu HH^*, Chen XL^*. Trans‑4‑hydroxy‑L‑proline catabolism byPseudomonadotain the ocean.Marine Life Science & Technology, 2025, 10.1007/s42995-024-00272-8.

7.Peng M, Chen XL, Zhang D, Wang XJ, Wang N, Wang P, Todd JD, Zhang YZ, Li CY^*.Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.Applied and Environmental Microbiology. 2019, 85(8). pii: e03127-18. Doi: 10.1128/AEM.03127-18.

8.Yang J, Zhong S,Chen XL,Yu Y,Zhang YZ,Su HN,Song XY,Peng M^*. A Direct Circular Dichroic Assay for Quantitative Determination of Peptide Enantiomers.ActaBiochemicaetBiophysicaSinica.2021, 53(10). 1412-1415. Doi: 10.1093/abbs/gmab104.

9.Chen XL^#,Peng M^#(co-first author), Li J^#, Tang BL, Shao X, Zhao F, Liu C, Zhang XY, Li PY, Shi M, Zhang YZ, Song XY^*. Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease fromPseudoalteromonassp. SM9913.ScientificReports.2017,7(1):15716.Doi: 10.1038/s41598-017-15971-9.

10.Teng ZJ, Li J, Wang P, Li CY,Peng M, Qin QL, Chen XL, Chen Y, Fu HH, Wang N^*, Zhang YZ^*. Meta-omics analysis reveals the marine arsenic cycle driven by bacteria.J.Hazard. Mater.2024, 476: 135137. Doi: 10.1016/j.jhazmat.2024.135137.

11.He XY^#, Liu NH^#, Liu JQ,Peng M, Teng ZJ, Gu TJ, Chen XL, Chen Y, Wang P, Li CY, Todd JD, Zhang YZ^*, Zhang XY^*. SAR92 clade bacteria are potentially important DMSP degraders and sources of climate-active gases in marine environments.mBio.2023, 14(6): e0146723. Doi: 10.1128/mbio.01467-23.

12.Yang H, Shang Z, Chen Y, Li F, Li K, Zhu H,Peng M, Yang J, Cai C, Ju J^*. Metabologenomics-Inspired Discovery and Combinatorial Biosynthesis-Based Diversification of Fungal O-Glycosylated Depsides.Org Lett.2024,26(39): 8317-8322. Doi: 10.1021/acs.orglett.4c03024.

13. Li CY^#, Crack JC^#, Newton-Payne S^#, Murphy ARJ, Chen XL, Pinchbeck BJ, Zhou S, Williams BT,Peng M, Zhang XH, Chen Y, Le Brun NE^*, Todd JD^*, Zhang YZ^*. Mechanistic insights into the key marine dimethylsulfoniopropionate synthesis enzyme DsyB/DSYB.mLife. 2022 Jun 15;1(2):114-130. Doi: 10.1002/mlf2.12030.

14.Wang Y^#, Wang P^#, Cao HY, Ding HT, Su HN, Liu SC, Liu GF, Zhang X, Li CY,Peng M, Li FC, Li SY, Chen Y, Chen XL^*, Zhang YZ^*. Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis,Nature Communications, 2022, 13(1): 566. Doi: 10.1038/s41467-022-28264-1.

15.Williams BT, Cowles K, Bermejo Martínez A, Curson ARJ, Zheng Y, Liu J, Newton-Payne S, Hind AJ, Li CY, Rivera PPL, Carrión O, Liu J, Spurgin LG, Brearley CA, Mackenzie BW, Pinchbeck BJ,Peng M, Pratscher J, Zhang XH, Zhang YZ, Murrell JC, Todd JD^*. Bacteria are important dimethylsulfoniopropionate producers in coastal sediments.NatureMicrobiology. 2019 Nov;4(11):1815-1825. doi: 10.1038/s41564-019-0527-1.

16.Shao X, Cao HY, Zhao F,Peng M, Wang P, Li CY, Shi WL, Wei TD, Yuan Z, Zhang XH, Chen XL, Todd JD, Zhang YZ^*. Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria.MolecularMicrobiology. 2019 Apr;111(4):1057-1073. doi: 10.1111/mmi.14211.

17.Li CY, Chen XL, Zhang D, Wang P, Sheng Q,Peng M, Xie BB, Qin QL, Li PY, Zhang XY, Su HN, Song XY, Shi M, Zhou BC, Xun LY, Chen Y, Zhang YZ. Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.Molecular Microbiology. 2017 Mar;103(6):992-1003.Doi: 10.1111/mmi.13605.

18.Wang N,Chen XL,Gao C,Peng M,Wang P,Zhang N,Li FC,Yang GP, Shen QT, Li SY, Chen Y,Zhang YZ,Li CY*. Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.Journal of Biological Chemistry. 2020 Nov 21; 296:100081. Doi: 10.1074/jbc.RA120.015952.

19.Li DD,Peng M, Wang N, Wang XJ, Zhang XY, Chen XL, Su HN, Zhang YZ, Shi M^*.Arcticibacterium luteifluviistationisgen. nov., sp. nov., isolated from Arctic seawater.International Journal of Systematic and Evolutionary Microbiology2017 Apr;67(3):664-669.Doi: 10.1099/ijsem.0.001690.

20.Li DD, Zhang YQ,Peng M, Wang N, Wang XJ, Zhang XY, Li PY, Xie BB, Chen XL, Zhang YZ, Qin QL^*.Erythrobacter xanthussp. nov., isolated from surface seawater of the South China Sea.International Journal of Systematic and Evolutionary Microbiology.2017 Jul;67(7):2459-2464. doi: 10.1099/ijsem.0.001991.

21.Cao HY, Wang P,Peng M, Shao X, Chen XL, Li CY*. Crystal structure of the dimethylsulfide monooxygenase DmoA fromHyphomicrobium sulfonivorans.Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):781-786. doi: 10.1107/S2053230X18015844.

22.Li DD, Liu C, Zhang YQ, Wang XJ, Wang N,Peng M, Song XY, Su HN, Zhang XY, Zhang YZ, Shi M. Flavobacterium arcticum sp. nov., isolated from Arctic seawater.International Journal of Systematic and Evolutionary Microbiology.2017 Apr;67(4):1070-1074. doi: 10.1099/ijsem.0.001804.

主要奖励及荣誉：

1.国家奖学金（2019）

2.3522集团的新网站优秀学术成果奖（2020）

3.3522集团的新网站优秀毕业生（2020）

4.3522集团的新网站“海右”博士学术论坛主讲人（2020）